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KMID : 0644120090220040019
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Journal of Oriental Gynecology
2009 Volume.22 No. 4 p.19 ~ p.27
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Acute Toxicity Study on Fermented Ojeok-san(Wuji-san) Extract in Mice
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Um Young-Ran
Cho Chang-Won
Ma Jin-Yeul
Park Hwa-yong
Lee Jae-Hoon
Lee Ji-Hye
Moon Hyun-Jung
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Abstract
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Purpose: This study was carried out to investigate the acute toxicity and safety of fermented Ojeok-san(Wuji-san) extract.
Methods: To evaluate the acute toxity and safety, 0(control group), 1250, 2500 and 5000 ㎎/㎏ of fermented Ojeok-san(Wuji-san) extract were orally administered to 20 male and 20 female ICR mice. After single administration, we observed survival rates, general toxicity, changes of body weight, and autopsy.
Results: Compared with the control group, we could not find any toxic alteration in all treated groups (1250, 2500 and 5000 ㎎/㎏).
Conclusions: LD50 of fermented Ojeok-san(Wuji-san) extract might be over 5000
㎎/㎏ and it is very safe to ICR mice.
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KEYWORD
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Ojeok-san(Wuji-san), Fermentation, Acute toxicity, Safety, LD50
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